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Engineering of key enzymes de novo in heterologous hosts provides one strategy for the rational improvement of enzyme cocktails.
In addition, they are amenable to rational improvement or ab initio design and suitable for high-throughput selection and diagnostic procedures (Gilbreth and Koide, 2012).
The rational improvement of microbial strains for the production of primary and secondary metabolites ('metabolic engineering') requires a quantitative understanding of microbial metabolism.
These three different approaches represent powerful tools for understanding the molecular basis for lipase enantioselective catalysis and can guide the rational improvement and tailoring of catalyst performance.
We concluded that our simulation model could function as a new tool for the rational improvement and design of metabolic and regulatory networks.
Advances in genetics and molecular biology have provided opportunities for genomic studies of these economically significant organisms and engineering of cultures that focuses on rational improvement of the industrially useful strain.
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Rational improvements to compounds of this class resulted in single-digit nanomolar enzyme and cellular activity against PLK1, and oral bioavailability.
Recently, the transport of synthetic drug and gene carriers has been investigated quantitatively with real-time particle tracking technology, providing new insight into particle behavior in complex biological environments that is guiding rational improvements in particle design.
However, the knowledge about the bottlenecks of glycerol growth in S. cerevisiae will be a valuable starting point for further rational improvements of these isolates or of already available commercial production strains.
Meanwhile French thinkers like Voltaire, Condorcet and Turgot converted the Christian idea of spiritual progress into a vision of rational human improvement unhindered by religious superstition.
In the 19th century, faith in the rational, moral improvement of mankind, along with a revival of religious enthusiasm, spurred the peace movement.
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