The definition of a rational evidence-based follow-up programme based on the risk of recurrence remains to be established and needs prospective evaluation in clinical trials.
Early and accurate detection of metastatic lesions in the liver, or exclusion of liver involvement, is a prerequisite for rational staging and follow-up of patients presenting cancers with the potential risk of developing metastases in the liver, as the first dissemination site.
The results may aid in the rational design of clinical follow-up studies.
Active monitoring has been described as a decision "between the clinician and the patient to not treat the condition and to intermittently reassess its status along some rational time course in follow-up" [ 14].
Our effort to comprehensively describe common genetic variation in the KLK3 locus on chromosome 19q13.33 should enable a rational approach towards the follow-up analyses of the role genetic variation plays on PSA levels and prostate cancer risk.
Although our findings are preliminary, they may offer a more rational and individualised basis for cardiac follow-up of patients receiving anthracycline-based chemotherapy.
Regarding cervical cancer, an intelligent decision making system may support physicians to improve the selection of protocols for monitoring, diagnosing, and treating women with intraepithelial lesions or cervical cancer or even support the rational selection and the patient-specific follow-up decision making for women who have been treated for high-grade lesions.
From this information, to provide a rational guide to determine the initial and follow-up BTX-A amounts for injection.
As a follow-up to this study, we recommend an analysis of the relationship between range and rational prescribing, taking diagnosis and comorbidity into account.
Developing rational targeted cancer drugs requires the implementation of pharmacodynamic (PD), preferably non-invasive, biomarkers to aid response assessment and patient follow-up.
