Sentence examples for rational extrapolation from inspiring English sources

Previous work in this area is reviewed and a model for a rational extrapolation of crystallization rate data to low temperatures is utilized.

Hence, a rational extrapolation would be that a portion of CTSD accumulated in an endocytic compartment – thereby causing an increase in its protein levels without proportional alteration in activity.

While the above scaling procedures have utility under predefined boundaries, PBPK models inherently account for both growth and maturation in a mechanistic manner and thus allow for rational extrapolation across the age continuum.

This allows better understanding of PK properties, more rational candidate selection, and extrapolation of dose levels, of routes of administration, and of data across species.

Computational molecular modeling methods aid the risk assessment process by providing a rational approach for some extrapolations in the evaluation of chemical hazard.

We end by providing a rational comparison between the long term loads extrapolation method and the environmental contour method for the three control configurations.

Moreover, where there is a need to provide guidance despite limited evidence, it is rational to draw upon evidence derived from elsewhere, such as extrapolation of findings from other populations, from expert clinical opinion and from patient and public consultation [ 46].

Many investigators explored the cyclic creep of concrete experimentally, but a rational mathematical model that would be anchored in the microstructure and would allow extrapolation to a 100-year lifetime is lacking.

40 Research is needed to more systematically quantify these harms because understanding when harms outweigh benefits is critical for rational treatment decisions, and better understandings of harm and the implications for the extrapolation of trial findings to real world populations will need to be systematically incorporated into existing guideline development frameworks like GRADE.

The methodology of the discovery of mechanisms is an extrapolation from past episodes of research on mechanisms and the result of a synthesis of rational reconstructions of several of these historical episodes.

The rational, data-driven approach tends to keep us stuck in the past and the present, reducing sustainability to mere extrapolation.