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Rational conversion of noncontinuous active regions of proteins into a small orally bioavailable molecule is crucial for the discovery of new drugs based on inhibition of protein protein interactions.
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A consequence of this view is that the process of coming to appreciate practical reasons will involve shaping the agent's motivational sensitivities and may itself be akin to a non-rational conversion rather than to rational deliberation from existing motives (McDowell 1995: 100 101).
The subsequent understanding provided the cornerstone that led to rational, structure-based conversion of the initial NBD small molecule viral entry agonists to full functional antagonists.
Each time Mike E. adopted a new world view, he was able to convince himself that his conversion was rational, even inevitable.
This conversion seemed rational as an LR?=?10 is considered sufficiently large to rule-in a disease and an LR?=?0.1 is considered sufficiently small to rule-out a disease [22], and whether an LR is 10 or higher, or whether it is 0.1 or lower is not substantially different for clinical reasoning purposes.
So far, a plenty of IDT-based polymers have been proved to deliver high power conversion efficiencies through rational molecular design.
He said his conversion was a gradual, rational process that began in his undergraduate studies of medieval art, philosophy and theology, including Plato and the New Testament.
The proposed molecular-level mechanism gives insights into rational design of efficient catalysts for the ethanol conversion into butadiene.
This study affords us a rational design of a high efficiency photocatalytic system for solar energy conversion.
Beside their inhibitory effect on prion conversion, these molecules could be used as fundament for rational drug design.
It is promising to further raise the power conversion efficiency if high quality absorber is coupled with rational optical design for effective photon management.
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CEO of Professional Science Editing for Scientists @ prosciediting.com