For target vessel revascularization, and the composite of target vessel revascularisation or myocardial infarction, we report a plot depicting Schoenfeld-like residuals against time because of the presence of time dependent hazard ratios (fig F in appendix 2).
timeDepEffects: List of time dependent variables.
Toxicity was concentration dependent (increasing with increased N/P molar charge ratio) and time dependent (duration of the incubation period) as previously described [ 18].
A test for proportional hazards using the Schoenfeld residuals was performed, and for covariates indicating evidence of non-proportionality, spline smooth estimates of time-dependent hazard ratios (HRs) with point-wise confidence bands were calculated [ 32].
Crossing the WT1 ratio of 50 (time-dependent, dichotomous: whether or not each WT1 measure exceeded the 50 threshold) was not considered as a variable in the survival analyses due to its 100% specificity (i.e, patients that did not relapse never had WT1 ratio greater than or equal to 50).
To quantify the impact of time-dependent neutropenia on survival, a Cox regression model was used to estimate the hazard ratio (HR) of death (Hosmer and Lemeshow, 1999).
After the selection of the plutonium/minor actinides thorium mixture ratio, the time-dependent neutronic behavior of the reactor grade plutonium and minor actinides and original fuels in a PBMR-400 reactor was calculated by using the MCNP code.
In parallel, both the IH and IP administration of Nano C60 increased the autonomous activity and the level of threonine 286 (T286) autophosphorylation of CaMKII, enhanced post-synaptic AMPA/NMDA ratio, and triggered time-dependent activation of ERK and CREB.
Next, we quantified the subsequent appearance of iPP daughter lamellae and determine the time dependent ratio between parent and daughter lamellae as a function of the flow strength.
Excess burnout time or the ratio of burnout time of the emulsions was dependent on the water concentration, indicating that less oxidation time was required for coke particles from emulsions than from heavy fuel oil.
Extended Cox-model adjusted for risk factors of dementia and time dependent coefficients, see online data supplement for full model, global null hypothesis likelihood ratio test P <.0001.
