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It boasts the best ratio of efficacy to not-wanting-to-jump-out-of-a-window-with-panic that I've been able to find in 10 years.
The parameter γ1 represents the log-odds ratio of efficacy associated to treatment 1 versus the reference treatment, and γ2 the log-odds ratio of efficacy associated to treatment 2 versus the reference treatment.
Taken together, these data indicate that that FV-162 is an orally bioavailable, selective proteasome inhibitor with a favorable ratio of efficacy to toxicity.
The ratio of efficacy (overall or recurrence-free survival) and risk (toxicity) should be considered when taking the decision to prescribe this combination.
This value shows the ratio of efficacy to toxicity helps to eliminate activity that may possibly be due to a general metabolic toxin [ 39].
18 Similarly, to estimate the vaccine's efficacy against asymptomatic infection in India, we adjusted the projected vaccine efficacy against severe infection by the ratio of efficacy against asymptomatic to severe infection reportedly conferred by the first naturally acquired rotavirus infection.
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For radiotherapy, the central pathways to increase the therapeutic index, i.e. the ratio of treatment efficacy to side effects, are reversal of radiation resistance in tumour tissue, enhancement of radioresistance in healthy tissue, increasing radiosensitisation in tumour tissue, and better confinement of the deposited dose to the tumour volume (Kwatra et al. 2013).
The odds ratio of the efficacy of epalrestat vs. control subjects was approximately 2 : 1 (4 : 1 in patients with HbA1c ≤ 7.0%).
The sample size required for 90% power to detect a hazard ratio of 0.6 (protective efficacy [PE] OF 40%, PE defined as [1- hazard ratio] ×100%) assuming alpha = 0.017 to correct for three pair wise comparisons was 1000 infants (250 per arm).
A 95% confidence interval (adjusted for interim analyses) for the hazard ratio of the primary efficacy outcome will be constructed.
66, 67 The pediatric bumetanide doses (see Refs 59, 68) appear to be based in part on this ratio of diuresis induction efficacy, as for example stated in an influential paper by Sullivan et al.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com