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Distribution usually occurs rapidly; the rate of distribution to organs or tissues is determined primarily by blood flow and the rate of diffusion out of the capillary bed into the cells of a particular organ or tissue.
Accordingly, this caused the decrease of shortage in warehouse inventories, the postponed orders, and the delay in responding to the customers' needs; at the same time, the loading and usage rates of distribution centers are increased.
Capturing the rate of distribution from plasma to the lung is important when obtaining relationships between PK and PD.
Although this study design allowed for estimation of the extent of distribution, the true rate of distribution could have been obtained using a more informative sampling design.
The rate of distribution to ELF and AC from plasma was in the model captured by the rate constants kELF and kAC.
The ELF and AC distribution model consisted of characterization of the rate of distribution of drug from plasma to ELF and AC by two distribution rate constant, kELF and kAC, respectively.
Second, assessing rates of distribution of responses, 5 items were omitted because the frequency of responses of "slightly agree" and "strongly agree" were about 95%.
If the rate of distribution is fast, the ratio of drug concentrations at the site of action and in plasma will quickly become constant.
Furthermore, the size of rilonacept (approximately 250 kilodaltons) may limit the rate of distribution from plasma to target tissues involved in a gout attack.
The increased diuresis did not cause hypovolemia as both esmolol and phenylephrine slowed down the rate of distribution of lactated Ringer's from plasma to interstitium.
Factors that can affect the rate of distribution are blood flow and the chemical features of a given compound, such as molecular size and polarity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com