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MCF-7 is a rather well differentiated tumour cell line, reflected by its oestrogen-dependent growth.
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Here, SK-Hep1 cells rather than the well differentiated HepG2, Hep3B and Huh-7 cells were more sensitive to L.obtusiloba extract.
Histologically, 11% of the samples were well differentiated, 33% moderately well differentiated and 56% poorly differentiated.
Moreover, when analysing the expression of TRPM8 according to breast cancer grades, we found that TRPM8 is rather over-expressed in grade I (well differentiated) and II (moderately differentiated) than in grade III (poorly differentiated).
Histological features (Grade of differentiation); well: well differentiated; mod: moderately well differentiated; poor: poorly differentiated.
Hence, it may be desirable to target CD133+ tumours that are of the poorly differentiated stage rather than well-differentiated tumours with apically expressed CD133.
The vertebral column was well differentiated.
We've eaten rather well.
Mozilo did rather well himself.
Britain does that rather well.
They're done rather well".
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