We have previously discovered that SpA has the properties of a B-cell superantigen, enabling interactions with conserved variable region framework subdomains of the antigen receptors of lymphocytes rather than the complementarity determining region involved in the binding of conventional antigens [ 1].
Analogous to our target prediction analyses with the novel transcripts described above, we were unable to perform a more comprehensive (based on more complex RNA-RNA interactions rather than simple complementarity alone) analysis of potential leishmania tsRNA-host target mRNA interactions due to the lack of appropriate tools for large datasets.
These findings suggest a fair degree of functional complementarity rather than redundancy among endemic symbionts of natural plant populations.
First, it stresses the complementarity rather than the antagonism of rational and intuitive modes of knowing.
The administration will continue to focus on economic healing, on increasing the country's ability to export and on expanding its world trade agenda in particular, by taking initiatives with countries of the European Union, such as to lead to economic complementarity rather than just a military relationship through the North Atlantic Alliance NATOO).
Inclusion and complementarity rather than exclusion of tribal medicine was the alternative suggested.
To find putative interaction sites, we look for complementarity rather than similarity/identity.
The identity matrix has to be modified to include complementarity, rather than similarity, while considering wobble G U pairs.
Notably, the (trifluoromethyl pyrazole, 1,3,4-oxadiazole, and indole scaffolds are thought to mainly interact with PRMT4 via shape complementarity rather than by polar interactions, except for two hydrogen bonds formed between the side chain of Y262 and the oxadiazole oxygen atom and between the hydroxyl og Y477 and a fluorine of the trifluoromethyl group.
These few positively charged residues are not conserved in closely related phages (supplementary Fig S1 online), suggesting that DNA binds to the active site mostly through shape-complementarity rather than charge charge interactions.
