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He went hitless in five games, with seven strikeouts, and when the minor league season ended on September 2 he was moved to Camelback Ranch to continue his rehab rather than being activated.
Indeed, rather than being activated, RTN1* may be stabilized by another binding protein that would prevent miR-195 from binding to RTN1* to exert a repressive effect.
Because Beclin1 silencing increases EBV gene expression and replication, stimulation of autophagy appears to represent the cellular response to the synthesis of the viral products rather than being activated by the virus to favor the early phases of lytic infection.
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ATF6 staining was increased in airway cells on PND1 compared with embryonic lung, while ATF4 staining did not change during this period (Fig. 6; Supplementary Figure 18), supporting the concept that ATF6, rather than ATF4, was activated in the stress response after birth.
Some investigators have hypothesized that mammary stem cells, rather than progenitors, are activated during pregnancy for alveoli production [ 37, 38].
Moreover, phosphorylation of ERK1/2 and Smad2/3 rather than Akt was activated in hepatic stem cells and mature hepatocytes.
Under starvation conditions or after ceramide treatment, JNK1, rather than JNK2, is activated and Beclin1 dissociates from Bcl-2 after the phosphorylation of amino acid residues (Thr, Ser and Ser) thus inducing autophagy [ 13, 92, 93].
Due to the mechanisms of action of NAC, it is conceivable that it would be easier to prevent certain pathways from being activated rather than to modulate already highly activated signals with redundant or alternative pathways.
Resistance can arise through mutations of the androgen receptor that result in the receptor being activated, rather than inhibited, by antiandrogen drugs.
Growing evidence has shown that cell death mechanisms, rather than being discrete, are activated by common pathways.
Furthermore, we found that MAPK in cumulus cells rather than in oocyte was activated immediately after EGF administration.
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