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This observation is most likely a result of proteolysis of its heparin-binding domain rather than alterations in its gene expression [20, 23].
These data indicate that the changes in RGC dendritic segregation induced by EE reflect a true variation in RGC circuitry rather than alterations in retinal architecture.
In addition we found that this increase in fatty acid oxidation appeared to be a consequence of increased levels of the fatty acid transporter FAT/CD36 at the plasma membrane rather than alterations in AMPK or ACC activity.
In support, recent bone marrow transplantations in neonatal collagen X Tg mice implicate the defective chondro-osseous environment, rather than alterations in hematopoietic precursors, such as trafficking or homing issues, as the locus for the observed hematopoietic defects (unpublished data).
These results highlight the importance of SDT when assessing attentional functioning, since it enables one to identify whether putative attentional deficits [35], [36] may be due to the use of different response strategies rather than alterations in attention.
However, the fact that naturally occurring mutations of Stat3 leading to its constitutive activation have not been identified implies aberrant growth factor signaling may play an important role in the constitutive activation of Stat3, rather than alterations in the gene per se [2].
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His earlier research, in the 1950's and 60's, delved into the theory that evolution occurs through duplication, rather than alteration, of genes.
Systems biology (SB), a recent trend in bioscience research to consider the complex interactions in biological systems from a holistic perspective, sees the disease as a disturbed network of interactions, rather than alteration of single molecular component(s).
An evolving approach, based on systems biology considers that a disease expresses a disturbance of the network of interactions underlying organismic functions, rather than alteration of single molecular components.
In contrast to prior work, we show that disruption of CaP60A in a cardiac specific manner results in cardiac dilation and dysfunction rather than alteration in heart rate.
So they rest content with making tactical adjustments at the margins rather than alteration of core premises and patterns of action.
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