Exact(13)
His earlier research, in the 1950's and 60's, delved into the theory that evolution occurs through duplication, rather than alteration, of genes.
Systems biology (SB), a recent trend in bioscience research to consider the complex interactions in biological systems from a holistic perspective, sees the disease as a disturbed network of interactions, rather than alteration of single molecular component(s).
An evolving approach, based on systems biology considers that a disease expresses a disturbance of the network of interactions underlying organismic functions, rather than alteration of single molecular components.
In contrast to prior work, we show that disruption of CaP60A in a cardiac specific manner results in cardiac dilation and dysfunction rather than alteration in heart rate.
So they rest content with making tactical adjustments at the margins rather than alteration of core premises and patterns of action.
Thus, the differences between the wild alga and the regenerated individual probably result from gene expression rather than alteration of the genome, especially the cpDNAs.
Similar(46)
This observation is most likely a result of proteolysis of its heparin-binding domain rather than alterations in its gene expression [20, 23].
Raastad et al. [44] recently suggested that myofibrillar disruptions, rather than alteration-contraction coupling failure, seem to be a main cause for the long-lasting reduction in force-generating capacity after eccentric exercise.
These data indicate that the changes in RGC dendritic segregation induced by EE reflect a true variation in RGC circuitry rather than alterations in retinal architecture.
In addition we found that this increase in fatty acid oxidation appeared to be a consequence of increased levels of the fatty acid transporter FAT/CD36 at the plasma membrane rather than alterations in AMPK or ACC activity.
In support, recent bone marrow transplantations in neonatal collagen X Tg mice implicate the defective chondro-osseous environment, rather than alterations in hematopoietic precursors, such as trafficking or homing issues, as the locus for the observed hematopoietic defects (unpublished data).
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