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Rather than activate the phones in the store, buyers are required to activate them via an Internet-connected personal computer.
When deterioration occurred within the area of specialty the junior staff would be more likely to call senior nurses and doctors within the specialty rather than activate the RRS.
Third, negative reward prediction errors are motivationally very salient but depress rather than activate dopamine neurons, including those activated by air puffs [ 36,37].
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Importantly, the MAPKKK MEKK3 had the opposite effect to LRRK protein overexpression on Wnt signaling, repressing rather than activating DVL1-mediated TOPflash activation (Fig. 2D).
Nonetheless, recent finding from Crabb and colleagues suggested that ethanol is capable of inhibiting (rather than activating) hydrogen peroxide-induced AMPK activation in hepatoma cells [23], suggesting a likely paradoxical role of AMPK in ethanol-elicited effects.
TFIIS is primarily an elongation factor and TFIIS knockdown should primarily affect the efficiency of actively transcribed genes rather than activating new pathways.
However, in contrast to cell culture data, the rGH-PAL activity was substantially repressed rather than activated in 100 nM T3 concentrations (Fig. 10D-D').
Moreover, the data indicate that it might be important for drug discovery strategies to maintain Cdk5 activity at wild-type levels, rather than activating or inactivating it excessively.
The counterintuitive observation that inhibitory FcγRIIB, rather than activating FcγRs, are required for enhancing adjuvant and anti-tumour activity of agonistic CD40 IgG1 mAbs supports this assertion (Li & Ravetch, 2011).
Now, Herman, Huang et al. show that shining light pulses for long durations onto neurons expressing a light-activated protein called channelrhodopsin-2 causes the neurons to become silenced rather than activated.
In some cases drug makers, rather than activating the toll-like receptors, hope to block the receptors as a way of damping the immune system.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com