Observed/expected ratios lower than 1 can be explained by the rather stringent criteria for inclusion into our study (for example, Cancer Registries include a variable proportion of DCO (death certificate only) cases).
This is probably due to the rather stringent requirements for predicting aerodynamic performance characteristics of flight vehicles, while flow devices involving low-speed or incompressible flow could be reasonably well designed without resorting to accurate numerical simulations.
Moreover, it must be recalled that the proceduralist accounts of autonomy attempt to set forth rather stringent conditions for authentic endorsement of values, in particular that such reflective endorsement (or non-alienation) not take place under conditions that effectively prevent reflection altogether (see Christman, 1991b, Mele, 1995, 186-93).
However, using a rather stringent cut-off for significance (p < 0.005; unadjusted p-values) provided more confidence in these data than using the frequently used threshold of p < 0.05.
The study had rather stringent inclusion criteria for the study subjects to obtain a homogeneous cardiac panel presumably vulnerable for the effects of air pollution (von Klot et al. 2005).
The rather stringent parameters employed for the transcriptome comparison could have led to the transcriptome differences herein observed, although the use of lower E-value thresholds (say E ≤ 1 × 10-5) mighaveave not contributed much to increase level of transcript homology, as suggested by a previous genome sequencing study in Eucalyptus grandis [ 87].
We used this rather stringent threshold to compensate for the inherent correlation in the scores between data sets (for e.g., we have multiple REV-ERB and BMAL1 ChIP-seq data) that is unaccounted for in the shuffling procedure.
Furthermore, we implemented a rather stringent and conservative threshold for statistical significance so that we likely underestimated the number of SMAs reported.
Since the fixation method routinely used in our laboratory is rather stringent (see below) and not appropriate for all antibodies, frozen sections were required for Cldn1, Ki67 and CD3 immunostaining [ 2].
For instance, if the cross-validation scheme used for model selection is rather stringent, then overly complex models get sorted out and one source of model selection bias is avoided [2],[2]].
But the fear of "Napsterisation" has led to rather stringent DRM measures in e- publishing.
