Interhemispheric comparisons, on the other hand, revealed a rather small intraindividual variability.
Since this variability is rather small, it should be possible to quite accurately estimate this population average from modest group sizes and to interpret statistically significant differences in group averages as being due to differences in scanner calibration rather than as differences of true mean BSUV between different groups.
As has been discussed in [7], assuming a suitable lesion and investigation independent value V ̄ r for Vr does not introduce sizable errors since the second term in Equation 1 is in general distinctly smaller than the first one, while its inter-lesion variability is rather small.
Furthermore, by including persons of the same age at a certain rather small time interval, we reduce variability due to age and time differences in exposure.
The use of five mice per group, a rather small number when considering the variability associated with the AIA experimental model, was compensated by the large number of screened conditions, thus providing new information on the effect of PLGA microparticles or SPION-containing microparticles on the synovial cavity.
No real reason was hypothesised, but the variability of the animal model response and the rather small number of animals per group could partially explain this trend.
From a ligand- or drug-design viewpoint, one is not dealing with a small variability in the "druggability" of a single pocket, but rather an ensemble-docking of radically different active sites, with a range of druggabilities.
Indeed, VT-linked genes (genes identified as viral clearance related) make a rather small input into the MV vector, which represents the pattern of overall gene expression variability of patients (Fig.3 and 4).
From a clinical point of view the variability in LDL-C modulated by rs2228671 genotypes might be considered rather small in comparison to the profound LDL-C lowering achieved in recent therapeutic trials (examples: CARE[31]: Δ1.1 mmol/L, Heart Protection Study[32]: Δ1.0 mmol/L,TNT[34]: Δ1.9 mmol/L )[34].
This can possibly be attributed to the variability in the measurement technique as mentioned above and the often rather small samples sizes in the different studies.
