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Monoallelic expression of the five genes is not coordinated at a chromosome-wide level, but rather regulated at individual loci.
There is emerging evidence that aging is not purely a cell intrinsic process, but rather regulated by interaction with the cellular microenvironment.
Since the phase of PER2::LUC expression was not systematically related to these other circadian parameters, this suggests that SCN phase heterogeneity is not determined by these factors but rather regulated by SCN network properties.
More studies are needed to uncover whether isomiRs are random degradation or rather regulated biosynthesis products, and whether the action of isomiRs is divergent or redundant.
The California attorney general said that the law did not inhibit free speech, but rather regulated the conduct of licensed professionals, and that the government had an established interest in barring practices deemed ineffective or potentially harmful.
A recent study as well as unpublished data from our lab suggests that proteostasis in IPF might be rather regulated on the level of 26S proteasome activation [3],[3]].
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Interestingly, we detected several genes whose expression was not down-regulated, but rather up-regulated during fasting.
In contrast, Bachofen, McLennan, and Morgan posited that the earliest societies were ruled by women and that the forms of kinship used by these societies were rather less regulated than Maine had suggested.
"The opportunity is in resale, when the apartments become free-market rather than regulated," said the source, a longtime player in markets across the U.S. "You'll have to look at how long you're in the game.
Rather than regulated denitrosylation, the effect we have described results in wholesale SNO dysregulation, which we predict will have important consequences for the behavior of host cells, and therefore the natural history of infectious disease.
In line with its signal transduction mechanism as a transcriptional activator, activated Notch1 mostly up-regulated, rather than down-regulated, the expression of target genes (Fig. 2C).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com