They are rather primed to be the object of what Kant calls a judgment of the agreeable, based on an "interested pleasure", in this case the titillation provided by the alluring depictions of attractive bodies and seductive poses.
The results presented in this study add further support to this concept as root colonization by IC1270 did not cause a strong constitutive resistance phenotype, but rather primed plants to hyper-respond to subsequently inoculated pathogens, resulting in excessive defense activation and enhanced resistance to M. oryzae.
Increasing evidence has suggested that QSCs are not in a dormant state but, rather, primed for activation and differentiation (Cheung et al., 2012; Crist et al., 2012).
Interestingly, when mESCs were exposed to EpiSC culture conditions, they displayed ES cell-specific marker expression of the primed PSC rather than that of the naïve state, with downregulated Nanog, Klf4, and Rex1, while maintaining Oct4 expression [ 17, 29].
The odds are singularly unexciting, however, with Cape Blanco looking primed to contribute rather more to proceedings than a diplomatic gesture.
This suggested that differences between mouse and human ES cells may reflect a developmental distinction between naive and primed pluripotent states, rather than species-specific differences (Nichols and Smith, 2009; Rossant, 2008).
Rapid MDBs formation in primed mice is rather non-specific, since it can be triggered by a variety of stress conditions including colchicine (but not by lumicolchicine), bile acids, bile duct ligation, several other toxins, and proteasome inhibitors which were unable to induce MDBs in the naïve animal (Zatloukal et al. 2007, and references therein).
Thus, the inclusion of CpG to the immunization cocktail did not lead to the recruitment of additional naïve T-cell precursors into the T-cell response, but rather influenced the differentiation course of primed T cells.
Because IL-10-producing, PD-1/PD-L1+Tim-3+CD8+ T cells appeared at a late time point postadenovirus infection (day 7), we hypothesized that liver-primed CD8+ T cells, rather than acting as effector cells, contribute to limiting local inflammatory responses by suppressing Teff cells migrating to the hepatic microenvironment.
Taken together, these data suggest that the BMP target gene Id1 does not drive overt mesoderm differentiation but rather maintains Cdh1 and helps to maintain a primed pluripotent state similar to that of the post-implantation epiblast, whilst imposing a proximal posterior (T+ Nanog+) epiblast identity that is primed for mesoderm differentiation.
The slow conversion observed in 5i/L/A is consistent with a reprogramming event toward a distinct cellular state, rather than adaptation to an identity closer to conventional (primed) human ESCs.
