Interestingly, we found that 1 does not bind to the active site but rather perturbs a set of residues in a distal site on CDC25B.
In this case, cholesterol does not improve but rather perturbs the organisation of sphingolipids and can even inhibit glycosphingolipid binding to amyloidogenic proteins (Ref. 52).
So reciprocally, it is possible that although hypomorphic mutations in Utp15p and Nhp2p, whose depletion results in early ribsome biogenesis defects, rather perturb downstream steps in the pathway.
On the other hand, it is now well-recognized that many functionally important genetic variants do not change the coding sequences directly but rather perturb gene regulation [ 7, 8].
The special cases when the interface cuts though grid points are handled carefully, rather than perturbing the cutting point away to apply the method for general case.
They are all indicators of polarity as they are anisotropic, in the rare cases when they are in conflict perhaps they should be teaching us something rather than perturbing us! 6) One view of PCP refers to a cell's perception of its orientation within a tissue, that is, where it 'thinks' anterior, posterior etc are located.
In particular, earlier studies failed to establish whether the two drugs acted as direct inhibitors of one or the two dehydratases or rather as molecules perturbing protein protein interactions within FAS-II in a way that indirectly abolished the activity of these enzymes.
Notably, however, developing hair germs evaginate rather than invaginate, thereby perturbing the epidermal organization.
However, the analysis indicates that ZHTc6 cells differentiate into more different cell types than appreciated previously, suggesting that overexpression of Oct3/4 alone does not completely determine the fate of ES cells, but may rather facilitate differentiation by perturbing the maintenance of self-renewal.
In George Lucas' "Star Wars" prequel films "Episode II: Attack of the Clones" (2002) and the aforementioned "Revenge of the Sith," the decision to render Yoda via CGI rather than puppetry perturbed some die-hard fans.
In cells expressing non-cleavable Rad21, we also observed aberrant anaphases, but it was the separation of chromosome arms that was perturbed, rather than separation of sister centromeres.
