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Based on our results, we propose that the key defect underlying the hyperphagic behavior in PWS is not defective regulation of energy homeostasis as had been proposed [19], [20], but rather defective control of meal termination.
8 Although berberine acts as a glucose- and lipid-lowering agent, it remains rather defective in terms of oral bioavailability.
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IPC-7 is rather a defective material, and TEM images show different types of defects in the material.
Finally, the TUNEL assay demonstrated that the decrease of myocardium cell numbers in the ventricle did not result from cell death, but rather from defective proliferation of ventricular myocardium, which led to a smaller heart with a thinning layer (Figs. 3E and 3F).
Interestingly, increased formation of autophagosomes rather than defective degradation was observed in NPC.
The loss of CD103+CD11b+ DCs in SIRPα mutant mice appears to reflect enhanced susceptibility of these cells to die by apoptosis rather than defective generation from DC progenitors.
Loss of DAF-3 by genetic null does not result in locomotion or embryonic lethality phenotypes, but rather, dauer defective animals [ 31].
This requirement was elegantly illustrated in a landmark study by Ubeda et al. showing that differences in the composition of the microbiota observed in TLR-deficient mouse strains reflected long-term divergence of the microbiota when the different mouse strains are housed in isolation from each other rather than defective innate immunity.
Bradley Campbell, the commissioner of the Department of Environmental Protection, said that rather than adopt defective rules, the administration scuttled the proposed regulations and then redrafted them to close the loophole somewhat.
These defects were not associated with a significant alteration in regulatory gene expression, but rather with a defective ectodermal epithelium and an abnormal disintegration of the cloacal membrane.
Bowers believes that the returned pieces were likely defective, rather than unsold.
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CEO of Professional Science Editing for Scientists @ prosciediting.com