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Contrary to the expectation, however, the inhibitory potency of 6 was not improved and that of 7 was rather attenuated by the replacement.
Further, most oncolytic adenovirus trials completed have utilized early generation viruses, which are rather attenuated in their replicative potential.
To our surprise, resveratrol did not promote, but rather attenuated the apoptotic effects of MG132 in cultured K562 cells.
In the current study, silencing of DIAPH3 expression in visceral SMC did not affect migration or proliferation, but rather attenuated PDGF-stimulated formation of lamellipodia.
In our case, however, PTHrP rather attenuated the effect of TNF-α (100 pg/ml) on astrocytic expression IL-6 (supplementary figure).
They showed that spontaneous intrinsic activity in the default mode network was not extinguished but rather attenuated and reorganized during a working memory task in healthy controls.
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17 Such misclassification would, however, not explain the findings presented, as the potential bias would rather attenuate the risk estimates.
It is now fairly clear that ORAs have little effect on initiation of feeding, but rather attenuates preference for "palatable diets" and eating behavior [ 21].
Interestingly, the cells react by not fully silencing the ES, but rather attenuating its activity to about 20%, probably by chromatin remodeling after histone methylation.
MSH2 depletion does not appear to enhance DNA repair, but rather attenuates the DNA damage response that is abnormally increased in FA cells.
While the exact mechanisms remain to be unravelled, a direct negative influence of MFG-E8 on neural inflammatory cell infiltration seems unlikely since MFG-E8 has been shown to rather attenuate neutrophil infiltration in acute lung injury [ 18].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com