For, while the leisured reading of a travel memoir by a noted navelgazer might offer an opportunity to identify with the author, there's something about actually watching it that rather alters the dynamic.
I've never wanted to depict just what I see, but rather alter things to find a deeper sense or meaning as though I am creating a living being that pulsates and moves with emotions and feelings.
None of the BMPs we examined exclusively direct differentiation to only one cell type, but rather alter the relative proportions of a specific cell type.
In addition to GPCRs, we also included in our analysis 7 genes encoding proteins that are not GPCR but rather alter GPCR pharmacology and/or coupling specificity.
The MSL1 lesions are not simple nulls, but rather alter the PEHE domain that recruits the MSL3 chromodomain and MOF ('males absent on first') histone acetyltransferase subunits to the complex.
Moreover, new molecular-targeted oncology treatments may not produce direct cell death, but rather alter biochemical pathways or cellular homeostasis, that may interact with classical radiation targets or produce new radiation targets [ 107].
However, identification of compounds in the Grb2 screening assay is not diagnostic of the mechanism of action of the compound; it is formally possible that the compounds are stabilizing, destabilizing, or not affecting stability, but rather altering EGFR oligomeric structure in a manner that impacts the magnitude or the kinetics of internalization and recycling.
The role of B-cell depletion in the activation of antigen specific T-cells in EAE is complex as B-cells do not directly impair T-cell function, but rather alter the balance between effector and regulatory function of these cells [ 35- 37].
Functional interactions with extracellular matrix molecules provide further mechanisms for the cellular regulation of fascin, although these adhesion conditons do not upregulate the protein but rather alter its subcellular distribution, either inducing or stabilising bundling of actin by fascin, or not supporting fascin protrusions (Kureishy et al, 2002).
The biologic events leading to the initiation and progression of MPNs are likely not only caused by the acquisition of genetic mutations, such as the JAK2V617F mutation, but may also due to epigenetic changes that do not affect the primary sequence of DNA but rather alter gene expression by remodeling chromatin.
