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A possible limitation of our methods is that we did not use matched pairs but rather adjusted for country-level location and age by using statistical modeling.
We did not perform heating of the water taps for decontamination before taking the sample as recommended in drinking water regulations, but rather adjusted our procedure to the suggestions for water surveillance in hospitals according to Pitten et al. [ 23].
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This likely introduced confounding to our pooled analysis, since crude outcomes, rather than adjusted odds ratios were reported for most trials.
We used height and weight as nutritional outcomes, rather than adjusted height and weight by age and gender, such as HAZ and WAZ as they are less straightforward to interpret [ 24].
As shown in Table 6, the overall estimates for each outcome were virtually unchanged by using least-adjusted rather than most-adjusted estimates.
As for amount smoked, these results show that the dose-related increase can be clearly seen using alternative key values (1, 10, 20, 30, 999), and using least-adjusted rather than most-adjusted RRs.
Nor are they affected by preferring least-adjusted, rather than most-adjusted RRs, with the estimates now 2.85 (2.59-3.15, n = 133) for COPD, 2.73 (2.52-2.95, n = 119) for CB and 4.16 (3.03-5.71, n = 30) for emphysema, slightly more RRs being included as some studies have sex-specific unadjusted RRs but only sexes combined adjusted RRs.
These results, which also include some meta-analyses by level of selected characteristics, show that the increase with amount smoked is also clearly evident using an alternative set of key values (1, 10, 20, 30, 40, 999), though numbers of available RRs are quite sparse for the higher values, and using least-adjusted rather than most-adjusted RRs.
Why? Lazio seems like a pleasant and apparently rather well-adjusted guy.
And yet I'd like to think I'm a rather well-adjusted individual, even though I can quote most of that sequence from memory.
Narayan's next novel The Bachelor of Arts (1937), was inspired in part by his experiences at college, and dealt with the theme of a rebellious adolescent transitioning to a rather well-adjusted adult; it was published by a different publisher, again at the recommendation of Greene.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com