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However, the essential roles of NK cells in the immune system are revealed in patients with NK deficiency (Orange, 2013), who have increased rates of malignancy (Orange, 2013; Morvan and Lanier, 2016) and are susceptible to herpesvirus infections, including varicella pneumonia, disseminated cytomegalovirus, and herpes simplex virus (Biron et al., 1989).
Older people had higher rates of malignancy and CVD.
Increased rates of malignancy such as hepatocellular, bile duct, and neuroendocrine carcinomas are also reported.
Overall rates of malignancy remained stable over time, and no increase was found with prolonged exposure.
There is also concern about increased rates of malignancy, although results have been conflicting.
Importantly, despite this variability, rates of malignancy in each category fell within expected ranges [ 10].
Similar(37)
Follow-up of patients in WOSCOPS for 10 years did not show higher rates of malignancies.
The numbers and rates of malignancies in the abatacept CDP are shown in table 4.
The incidence rates of malignancies at 6-month intervals did not increase with increasing exposure over time.
Rates of malignancies reported in adalimumab clinical trials across all indications were 0.7 events/100 PYs for malignancies excluding lymphoma and NMSC, 0.1/100 PYs for lymphoma, and 0.2/100 PYs for NMSC; these rates were generally similar to previously reported rates.
In the largest study on the incidence rates of malignancies among first-time recipients of deceased or living donor kidney transplantation (n = 35765) the rates for most malignancies are higher after kidney transplantation compared with the general population [ 7].
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