Unexpectedly, liposomal irinotecan was also seen to have much higher rates of grade 3 or 4 events of diarrhea and nausea, as seen in Table 4.
For instance, after an education reform in Malawi, the average age of students declined, due to lower rates of grade repetition; and the reduction in the time girls remain in school substantially weakened the 'incapacitation' effect (Grant 2015).
Five of 17 sites had significantly (P <.05) different crude incidence rates of grade 3-4 IVH (odds ratios [OR] 0.2, 3.2, 2.6, 2.1, 1.9) than the hospital with median incidence.
However, education quality is weak, producing high rates of grade repetition and dropout.
Rates of grade 3/4 neurosensory toxicity were similar with both regimens (17%).
Rates of grade 3 4 hyperbilirubinemia were 8%, lipase elevation 15%, and hyperglycemia 13%.
The corresponding rates of grade 3 4 thrombocytopenia were 13%, 27%, and 29%.
After dose reduction, the rates of grade 3+ diarrhoea decreased from 30%to16%6%.
For the patient groups listed in Table 2, the rates of grade 3 GIT toxicity range from 9 to 25%, while the rates of grade 3/4 haematologic toxicity range from 22 to 29% for the different subgroups.
Reported rates of grade 3/4 diarrhoea of have been reported with three weekly CapOx-B regimens [ 16].
In the CML-AP study, the corresponding rates of grade 3/4 neutropenia and thrombocytopenia were 21%and35%5%, respectively.
