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Monotherapy antiepileptic drug (AED) trials can optimally provide information concerning efficacy and tolerability of one drug compared with placebo, as well as to different doses or rates of administration.
Two hundred eighty (87%) children received oseltamivir, with no difference in rates of administration between the ICU and the floor.
Although this practice was observed in all hospitals, the rates of administration varied across countries (range 62% to 92%) and hospitals (range 44% to 100%).
However, the advantage of different rates of administration can only be reliably investigated in clinical trials that specifically investigate the different modes and rates of administration of a particular intervention.
The details of drugs, doses and rates of administration to be documented are on the data sheet.
Such studies will also guide on the appropriate routes of administrations and the optimum rates of administration of these agents.
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Numerical simulations show that, with the current rate of administration of antiretroviral treatment (to HIV-infected individuals), HIV burden decreases with increasing PrEP coverage.
To evaluate the effect of rate of administration of propofol or alfaxalone on induction dose requirements and incidence of postinduction apnea (PIA) in dogs following premedication with methadone and dexmedetomidine.
The factors studied, according to a center of gravity design, included the solubility of a model drug, different grades of polyvinylpirrolidone (PVP), the polarity and the rate of administration of the granulation solution, the atomizing air pressure, the inlet air pressure and rate.
The factors studied, according to a center of gravity design, included formulation (solubility of a drug, different grades of polyvinylpyrrolidone, the polarity of the granulation solution) and processing factors (the rate of administration of the granulation solution, the atomizing air pressure and the fluidizing air rate).
Also, no bolus or change in the rate of administration of vasoconstrictor and anaesthetic agents was performed during this period.
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