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As for the neural mechanism underlying timing, that is ".the neural properties that are actually sensitive to time rather than involved into the readout" [67], several modelling approaches (climbing firing rates models) [68] [70] propose that a particular pattern of neural activity, observed during tasks involving fixed temporal intervals, may carry duration information.
"To date, the CMA has produced no evidence to demonstrate that the conduct which is the subject of the CMA's Decision had any effect on the rates models represented by Viva received for assignments; this is because it did not have any such effect".
Because of differences between observed and simulated mortality rates, models parameterized with simulated mortality rates suggest a greater benefit of fuel treatment than using an observationally parameterized model.
We simulate data for tumors having different growth rates, models for cell division, and numbers of cancer stem cells (CSCs) at various stages of their development (numbers of generations of cell division) and plot the average estimates for the three different epigenetic distances: between half (BH), within half (WH) and within gland (WG) for various parameter settings (Figure 6).
To estimate the percentage change in STI rates, models with log-transformed STI rates as the outcome were also estimated.
(Note that we use the term "relaxed clock" throughout this paper to simultaneously refer to both independent and correlated rates models).
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The substitution rates modeled here are typical for nuclear genes across a diversity of organisms [17].
The "equal rates" model estimates one parameter of transition between all possible states.
The correlated rates model has a large number of parameters but is also more restrictive than the independent rates model.
Under the correlated rates model, rates on branches are dependent on branch durations and the rate on the ancestral branch.
This effect was more noticeable under the independent rates than the correlated rates model.
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