For example, if in a particular comparison, the first sample compared has high expression in genes promoting a certain pathway and the second sample has increased expression in genes repressing that pathway, it rates that pathway as more significantly different than if the DEGs are randomly distributed through the pathway.
The cells using the higher rate pathway (such as fermentation) will grow faster, even though they exploit the common resource inefficiently [ 81].
Other top-rated pathways include molecular mechanisms of cancer, NF-κB signalling and several interleukin (IL) signalling pathways (IL-4, IL-6, IL-17).
Pathways in HER2+ are a mixture of TP53 (mutation rate 72%) related pathways and PIK3CA (mutation rate 40%) related pathways.
Patients' acceptance of the recommendations of the pathway was rated high by the physicians.
TCGA: The Cancer Genome Atlas EGAA: The European Genome-phenome Archive; GBM: Glioblastoma multiforme; DEGs: Differentially expressed genes; FDR: False discovery rate; PPs: Pathway profiles; RPPs: Reference pathway profiles; CEP: Common enriched pathway.
The production of North Atlantic Deep Water: sources, rates, and pathways.
The frequency of oxic: anoxic oscillation clearly alters both the rate and pathways of lipid degradation in surficial sediments.
In addition, an existing model for the combustion of MCH is updated with new reaction rates and pathways, including substantial updates to the low-temperature chemistry.
Despite a clearer understanding of the processes that control the onset and propagation of instabilities, resultant plume patterns and their migration rates and pathways do not appear amenable to prediction at present.
Furthermore, a chemical kinetic model for the oxidation of trans-decalin has been developed with new reaction rates and pathways, including, for the first time, a fully-detailed representation of low-temperature chemical kinetics for trans-decalin.
