Because of variations in heart rate tolerability between individual animals, we made comparisons with penultimate and ultimate tolerable heart rates to detect physiological changes occurring close to the toleration limit both during normo and hypothermia.
Secondary study end points included clinical response rate, tolerability, completeness of tumour resection (R0 resection vs R1 or R2 resection), ypT and ypN categories, operative mortality and median overall survival (OS), event-free survival (EFS).
Furthermore, both patients and physicians rated tolerability over 2.5 points on a 4-point Likert scale during the entire follow-up.
Although the median PFS times for sorafenib and IFN were similar (approximately 5.7 months), sorafenib was interpreted as having superior clinical benefit because of improved response rates, tolerability and quality-of-life assessments.
The primary endpoint is progression-free survival, and secondary endpoints include objective tumor response rates, disease control rates, safety, tolerability, and overall survival.
Afterward, the scientists asked the volunteers to rate the tolerability or unpleasantness of the session, on a scale from 1 to 20.
To determine the completion rate and tolerability of short-course rifamycin and pyrazinamide treatment of latent tuberculosis infection (LTBI) in HIV-infected patients through a comprehensive community-based program.
PURPOSE: A phase II study of dasatinib, an inhibitor of multiple oncogenic tyrosine kinases including Src, was conducted to evaluate 16-week progression-free rate and tolerability in patients with previously treated metastatic breast cancer (MBC).
The key study parameters were the objective and subjective symptoms, time to resolution (sourced from recordings made by the parent(s)/legal guardian in the patient diaries), co-medication, adverse drug reactions (ADR) and global assessments of the effectiveness (responder rate) and tolerability.
Upon procedure completion, patients were asked to rate procedure tolerability and pain levels.
Procedure feasibility was assessed prospectively through technical success rate, procedure tolerability, quality of life, and radiographic outcomes.
