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In the context of CRT, the effectiveness of such rate control and rate regularization algorithms combined with the use of rate control drugs has not been investigated in an RCT.
These features include ventricular rate regularization (VRR) which consists in performing BVP, which 'overrides' intrinsic rhythm, through faster ventricular-paced depolarization allowing to reduce short cycles through retrograde concealed penetration of the AV node.
Tailorings of other device parameters that could potentially affect the %VP, such as rate-adaptive AV, automatic post-ventricular atrial refractory period, conducted AF response (i.e. ventricular rate regularization during AF), lead impedance trend which collects lead impedance data during pacing, and so forth, were also committed to each participant clinician.
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Then, we select 0.01 as the values of learning rate and regularization.
During the training, we used the following meta parameters: (learning rate) γ=0.02, (regularization factor) λ=0.025 and ε=0.00001.
Studies in patients with HF presumably due to sustained tachycardia (as seen in uncontrolled AF) do indeed establish the potential to reverse systolic dysfunction after control of ventricular rate, whether through regularization of rhythm or blocking of atrioventricular conduction.
In general, for an ill-posed problem, the convergence rates of the regularization solution can only be given under a priori assumptions on the exact data.
In a Banach space setting, the source inequality (30) has already been used in [36,50] to derive convergence rates for Tikhonov regularization with convex functionals and in [34] for multiparameter regularization.
The convergence rate of the accelerated regularization was investigated theoretically when the right-hand side was corrupted by noise.
In this way the regularized unbounded-periodic Green's functions can be implemented in an FFT-based Poisson solver to obtain a convergence rate corresponding to the regularization order of the Green's function.
For Tikhonov regularization, convergence rates have been derived in [3,6,23,36,46,47] in terms of the Bregman distance.
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