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We usually perform femoral releases in some pathologies such as congenital short femur on in massive lengthenings where soft tissues will not stretch at the same rate of the bone and their tension can create joint contractures.
However, these harvesting procedures have disadvantages, such as prolonged operating time, donor site morbidity, hospitalization [9, 11 13], sensory disturbances [14], and unpredictable resorption rate of the bone grafts [5, 15].
To evaluate relative changes in bone volume and resorption rate of the bone graft material, three dimensional measurements were obtained by cone-beam computed tomography (CBCT) immediately and at 4 months after the bone graft in all subjects (Fig. 2).
In order to evaluate relative changes in bone volume and resorption rate of the bone graft material, CBCT radiographs were taken immediately and at 4 months after the bone graft in all subjects.
After the calcium load was removed, the rate of the bone remodeling process may reverse [ 40].
However, residual inter-body distance has a direct impact on the survival rate of the bone graft after debridement [ 23 ].
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Moreover, a material's resorption rate should match the formation rate of the new bone tissue [ 29].
In addition, inhibition of LRP4 by a specific antibody increased the rate of bone formation and bone mass in mice [ 55].
Experts think the fractures happened because of the way the drugs work: by slowing the rate of bone remodeling, the normal process by which injured bone heals.
Hyperprolactinemia, however, has a direct impact on the rate of bone metabolism, both in bone formation and in bone resorption [ 38].
A single drug or combination of drugs that dissociates bone resorption from bone formation could decrease the rate of bone resorption while increasing the rate of bone formation, with the potential for improved clinical outcomes compared with current drug therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com