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As expected, dysgeusia and application site pain were the most commonly reported tolerability issues; most TEAEs were mild, however, which may have been a factor in the high rate of study completion (77.5%).
The discontinuation rate of study medication was similar in both randomized groups, steadily increased over time, and averaged 10% over the follow-up period of 5 years (Table 1 and Figure 1).
Another limitation is the high dropout rate of study participants.
Less commonly, the intervention itself necessitates a more frequent rate of study visits.
Data from the updated analysis (based on 77 % event rate) of Study 305/EMBRACE were used in this analysis.
There was also an overall high rate of study completion (>65%) and a low rate of AE-related discontinuation (9%).
Similar(26)
Since then, the publication rate of studies using SPT has been accelerating.
Open image in new window Fig. 1 The growth rate of studied protozoan organisms related to their pathogenic bacteria consumption.
Thus, it is possible with the current test battery to reduce the inter-test interval to facilitate the rate of studying and identifying behavioral phenotypes in mice.
Brown et al. [ 32] evidenced a 26%to50%50 % rate of studies ascribing greater inferential strength than the study design warranted.
The production rate of studies has dramatically increased over the past 5 years compared to 20 or 30 years previously.
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