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In patients with VA-LRTI, rate of prior antibiotic treatment was significantly higher in IC compared with non-IC patients (80%% vs 66%%, p = 0.001).
The higher rate of prior year rapid cycling in the Stanford compared to Argentinian cohort (36.2% vs. 12.4%) could be related to the higher rate of early onset (≤21 years) in the Stanford compared to Argentinian cohort (78.3% vs. 38.6%).
Our finding of higher rate of prior suicide attempt among BD patients with vs. without comorbid lifetime ED is consistent with multiple prior studies (Brietzke et al. 2011; Fornaro et al. 2010; McElroy et al. 2011, 2013).
However, the sample from the United States had a higher rate of prior year rapid cycling, as well as younger bipolar disorder onset age (mean ± SD, 17.9 ± 8.4 vs. 27.1 ± 11.4 years) and more severe clinical morbidity, though there was no significant difference in terms of the total duration of the illness.
This could be attributable to the high rate of prior PKP found as a risk factor in our study as the rate of surgical intervention required was much higher in patients with prior PKP (47 %) than in contact lens wearers without prior PKP (36%%).
Although the significantly lower rate of bipolar I disorder could account for the Stanford compared to Argentinian cohort significantly less often having a history of prior psychiatric hospitalization, the potential factors contributing to the Stanford compared to Argentinian cohort having a significantly lower rate of prior suicide attempt remains to be established.
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For each of these testing modalities, rates of prior testing exposure were higher for men than women.
The Argentinian sample had more unfavorable demographics and higher rates of prior psychiatric hospitalization and prior suicide attempt but a better social outcome.
However, the difference in rates of prior year rapid cycling did not appear to be related to rate of antidepressant administration, which was similar across the two cohorts.
Conversely, the sample from Argentina had higher rates of prior suicide attempt (45.7% vs. 30.8%, p < 0.0001) and history of psychiatric hospitalization (55.0% vs. 37.8%, p < 0.0001).
In the years ending January 2013, 2014 and 2015, the company grew from $6 million to $43 million to $174 million, respectively, topping the growth rates of prior enterprise speed demons such as Riverbed, DataDomain and GGV-backed stars such as Nimble Storage and Isilon.
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