Exact(37)
A missense mutation may be involved in regulation of AQP-5 expression in response to cigarette smoke extract and shear stress, however the functional variant in human AQP5 responsible for differential rate of lung function decline and its mechanism of action is yet to be identified.
Considering the reduced rate of lung function decline in postmenopausal patients, future studies will likely require enhanced study designs, such as selective enrollment of those with prognostic biomarkers predictive of decline.
Rate of lung function decline (RLFD) (as FEV1percentt predicted/yr) is a robust measure of CF therapeutic efficacy rarely used as a study endpoint, in part due to uncertainty of sample size requirements.
Polymorphisms in AQP5 were associated with rate of lung function decline in continuous smokers with COPD.
Collectively our results implicate AQP5 as a novel candidate gene for rate of lung function decline and COPD.
Genetic variants in the AQP5 gene might be associated with rate of lung function decline in chronic obstructive pulmonary disease (COPD).
Similar(23)
Rates of lung function decline were not different for different SGRQ thresholds.
Patients with chronic P. aeruginosa infection have increased rates of lung function decline, health care utilization, and reduced survival [ 2- 4].
Hypomethylation of transposable elements may or may not be causally linked to lower lung function and faster rates of lung function decline.
Patients with MRSA have increased rates of lung function decline [ 31] and are less likely to recover lung function following PEx [ 32].
In particular, LES has been associated with increased rates of lung function decline, exacerbation frequency and progression to end stage lung disease [ 2, 10, 11].
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