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All formats lowered the rate of lethality despite the > 100-fold molar excess of drug to antibody binding capacity.
Vibrio harveyi is an opportunistic human pathogen that may cause gastroenteritis, severe necrotizing soft-tissue infections, and primary septicemia, with a potentially high rate of lethality.
We observed a high rate of lethality during the L4 molt at 25°.
SAFB1−/− mice display severe defects, including a high rate of lethality and dwarfism, and, additionally, the males are infertile (Ivanova et al., 2005).
As a control, we found that embryos have a normal rate of lethality around 12% when development occurred at room temperature only (black curve in Figure 4b).
SSRI are increasingly the first line choice of anti-depressant because of their tolerable side-effect profile and low rate of lethality if taken in an overdose [ 3].
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If all these embryos could not survive until birth, the rates of lethality in CKO matings would have been close to 100%.
These defects are not rescued by zygotic SUMO expression since embryos produced by GLC females mated with wild-type males had similar high rates of lethality and a comparable spectrum of defects as those embryos produced by GLC females mated with heterozygous males.
This mutant models many aspects of ATD, but is difficult to analyse owing to high rates of lethality.
To determine if the absence of Fus1 altered latency of death after WBI, higher doses of 9 and 10 Gy that cause high rates of lethality in WT mice were used.
From extensive breeding and genotyping analysis, we have found the knockout of Cdk2ap1 resulted in very high penetrating rate of embryonic lethality.
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