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This enzyme is over-expressed in several cancers, and its rate of expression is correlated to the degree of aggressiveness of tumors, which makes it a new and attractive therapeutic target.
HIF2α protein was less frequently expressed in cases with a medium microvessel density (MVD); a high rate of expression was noted in cases with both low and high MVD (P = 0.006).
The production rate of expression change of the downstream target is a sigmoidal function of the upstream regulators.
When the rate of expression is low, however, detection occurred five PCR cycles earlier in the one-step method than in the two-step method.
This simple analysis leads to a formulation of a model where the rate of expression of a given gene transcript is proportional to the regulator concentration and its weight, transferred by a sigmoidal function, and is reduced by degradation.
We first examined whether glycosylation-related genes showed a higher rate of expression changes than all other genes (Table 1), which may indicate a prominent role for glycosylation alterations in EMT.
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Therefore CLR algorithm was selected for network inference for our work, as we required all the edges in our network to be also sequence-matched besides expression-correlated, reducing the false positive rate of expression-inferred edges.
We have identified elevated rates of expression and network connectivity among broadly expressed genes, and among disease-associated tissue-specific genes.
Duplicate pairs were divided into two classes: symmetric versus asymmetric rates of expression divergence.
For statistical analysis, the intensity of HDAC expression was grouped into low vs. high rates of expression.
These include elevated rates of expression and network connectivity in housekeeping and disease-associated tissue-specific genes.
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