This table suggested that the overlap rates of endpoint E are always greater than those of endpoint D. For normal models, the number of features for both endpoints have no significant difference (F = 0.9507, T-test = 0.5748) and there is either no significant difference for that of swap models (F = 0.1236, T-test = 1.2238, degree of freedom = 23.6263).
Among baseline characteristics, higher sUA, presence of tophi, and impaired renal status significantly (P < 0.001) and independently affected achievement of the primary endpoint: higher sUA and tophi were associated with lower rates of endpoint achievement, and subjects with mild renal impairment had uniformly higher rates of reaching goal sUA than subjects with normal renal function (Table 2).
Sensitivity analyses that explored the implications of the uncertain key parameters showed that model outcomes were most sensitive to vaccine price per dose, discount rate, case-fatality rate of primary endpoint pneumonia, and vaccine efficacy against primary endpoint pneumonia.
Survival curves were significantly different between the groups (P<0.0001; Fig. 5), with the rate of reaching endpoint in the CR mice (i.e., the hazard ratio) being 3.1-fold higher (95% CI: 2.9, 10.7) than the AL mice.
It is also estimated that the rate of composite endpoint within 3 year period of time is 40%.
After an average follow-up of 25 months, active treatment reduced the rate of composite endpoint (stroke and CV events) by 40% and mortality by 43%, both statistically significant.
Patients with a low CFR had a significantly higher event rate of cardiovascular endpoints compared to patients with higher CFR [ 6, 7].
However, applying a worst-case scenario in which discontinued patients are assumed to be non-responders (that is, did not achieve ≥30% reduction in pain VAS) still suggests a substantial treatment benefit, with a responder rate at endpoint of 45.7%.
The drug has been shown to cut the rate of a combined endpoint cardiovascular death, heart attack or stroke compared to clopidogrel.
The primary objective of the study is to compare incidence rate of a composite endpoint between BCM group and control group.
A heart failure self-management program designed for patients with low literacy reduced the rate of the combined endpoint of hospitalization or death.
