Sentence examples for rate of catastrophe from inspiring English sources

Dynamic instability is typically characterized by the rate of catastrophe events and the filament polymerization speed.

Stathmin binds tubulin heterodimers at the microtubule ends and increases the rate of catastrophe through a GTP hydrolysis-dependent mechanism.

Thus, the rate of catastrophe is k, the GTP-tubulin off-rate, and the mean lifetime is independent of tubulin concentration.

More specifically, the concept of a galactic habitable zone incorporates various factors, such as metallicity and the rate of major catastrophes such as supernovae, in order to calculate which regions of the galaxy are more likely to form terrestrial planets, initially develop simple life, and provide a suitable environment for this life to evolve and advance.

and show a ∼hundredfold slower rate of post-catastrophe shrinking (bottom; N = 16 for wild-type and T238A, bars show s.e.m .. DOI: http://dx.doi.org/10.7554/eLife.10113.003 The β T238A mutation was previously identified by virtue of drug- and temperature-sensitive phenotypes that were consistent with hyperstable microtubules (Thomas et al., 1985).

Stathmin is a phosphorylation responsive regulator of microtubule (MT) dynamics that increases the catastrophe rate of MTs (depolymerization or shrinkage phase of individual MTs) in a dose-dependent manner [34].

The β T238A mutation stimulated spontaneous nucleation and reduced the frequency of catastrophe and the rate of shrinking, all without substantially affecting elongation.

Our studies now reveal that the β T238A mutation affects microtubule dynamics by dramatically reducing the frequency of catastrophe and the rate of shrinking, and that the mutation affects microtubule structure by attenuating post-GTPase conformational changes in the lattice.

Based on the central role of allostery in controlling the frequency of catastrophe and the rate of shrinking, we speculate that cooperative conformational linkage in the lattice amplifies the individual response to nucleotide.

Whereas paclitaxel is less effective in suppressing the growth rate and catastrophe frequency of purified α/βIII tubulin, ixabepilone markedly suppresses the dynamic instability of α/βIII dimers [ 31].

Indeed, β C354A or β C354S substitutions dramatically reduced the rate of microtubule shrinking and the frequency of catastrophe (Gupta et al., 2002).