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Efficacy end points analysed included the rate of breakthrough episodes of HE and HE-related hospitalisations.
Rate of breakthrough overt HE episodes, hospitalisations and incidence and rate of adverse events (AEs) were analysed during RCT and first 6 months of OLM.
In the past, the use of monoclonal antibody to the HBV surface antigen led to an unacceptable rate of breakthrough infections.
At our centre the rate of breakthrough infections under posaconazole (5.3 %) was similar to the study by Ullman et al. [ 4] who included only patients with GvHD.
The objectives of this study were to compare the rate of breakthrough fungal infection, adverse drug events and costs associated with these prophylactic regimens.
Xu et al. found that micafungin was associated with a lower rate of breakthrough infection compared with fluconazole in the prophylaxis [ 32].
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The rates of breakthrough infection were comparable.
Increased rates of breakthrough RSVH have been noted with infants who have received less than full-season dosing.
Micafungin is indicated for prophylaxis against Candida infection in other high-risk patient groups [ 28, 29]; low rates of breakthrough IFI were observed for micafungin 50 mg (1.6%) and fluconazole (2.4%) in a trial comparing these agents in hematopoietic stem cell transplant recipients [ 30].
The effect of flow rate on breakthrough performance at the above operating condition for CLR and CR is shown in Fig. 5a and b, respectively.
In adsorption process, in addition to concentration of the loading sample solution and diameter-to-height ratio, the effect of loading flow rate on breakthrough curve was also investigated.
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