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In the Cdc42 cycle, the level of Gβγ affects the rate of activation of Cdc42 (C42) to its active form (C42a) through a cooperative Hill term (k0 term).
The autoactivation rates of both mutants are indeed about sixfold greater than that of the unmutated enzyme and comparable to that of the SH2-kinase module (the rate of activation is estimated from the slope of activity vs time, and is only a rough measure because of non-linearity; Figure 4C).
Muscle activation by photolytic release of Ca2+ and ATP suggested that the altered contractility was best described as a reduction in the rate of activation of noncycling actomyosin crossbridges to activated, cycling states.
It has been established that the active form increases its own rate of activation via various self-recruitment mechanisms (Raftopoulou and Hall 2004; Li et al. 2003).
The rate of activation will depend on the concentration of the activating electrophile and the receptor target.
Both action preparations [i.e. PA(a 1 ) and PA(a 2 )] are activated at time point 2 and, more importantly, with the same rate of activation strength until time point 15 (this highlights the non-biased effects in early action formation).
Let's also suppose that the average rate of activation of any given synapse is low so that temporal summation is linear.
Heteromeric XtKir4.1/XtKir5.1 channels exhibit similar macroscopic current properties to rat Kir4.1/Kir5.1 with a faster time-dependent rate of activation.
The saturation value of discharge capacity and the rate of activation during the charge-discharge cycling were remarkably enhanced by the surface modification with Co and Pd coatings.
Crevice corrosion initiated more rapidly, and the rate of activation of propagation increased, as the temperature was increased over the range 85 135 °C.
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These data indicate that the enhanced rate of activation-induced apoptosis in Nur77Tg T cells renders them more susceptible to control by Nur77-resistant Tregs.
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