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From this null distribution, we estimated the false-discovery rate of a recurrence score for a module of size-class k as: <img src="http://journals.plos.org/plosone/article/asset?id=info?doi/10.1371/journal.pone.0018968.e009.PNG" class= inline-graphic"/> where 1(x) is the indicator function equal to 1 if the argument x is true and 0 otherwise.
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The severity and poor prognosis of BD reflect the high rate of recurrence, with a mean recurrence rate of 60% within 2 years of an index episode, despite medications (Geddes and Miklowitz 2013).
TNBC has been considered a more aggressive breast cancer subtype with a higher rate of distant recurrence and a poorer prognosis [ 19, 20].
Clinically, the invading tumor manifests as a slow-growing, painless mass that is characterized by a high rate of local recurrence and a low rate of metastasis.
Women presenting with TNBC also have a higher rate of distant recurrence and a poorer prognosis than women with other subtypes of breast cancer.
In the majority of cases tumors grow multifocal and show a high rate of recurrence with a poor prognosis [ 2].
One of the subtypes, which we defined, gathered tumours with specific bioclinical features including a low rate of recurrence within a 5 year follow-up.
In the present study, patients with VEGFR-1 mRNA overexpression experienced a higher rate of recurrence and a poorer prognosis compared to VEGFR-1-negative patients.
One prospective observational study reporting the rates of seizure recurrence after AED taper initiated 3 months or 1 year after surgery found an eventual rate of seizure recurrence similar to a small group of historical controls.
These patients have a rate of distant recurrence of ∼5% after 10 years of follow-up.
MPNST is a very aggressive tumor, with a high rate of local recurrence and distant metastasis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com