Therefore, direct measurements of the switch kinetics in the sarcomere are required to test for the possible role of cTn in rate-limiting force development/relaxation.
Simultaneous measurements of force and intracellular [Ca2+] in intact cardiac trabeculae have shown that the rate of myoplasmic Ca2+ increase/removal does not rate-limit force development/relaxation (4, 5).
Regardless of the anger in the community, which clearly has been discounted as a small minority in Twitter's game plan, the clarity of Twitter's rate limiting and brute force approach in managing its developer community now stand in sharp contrast to FriendFeed's approach.
The pseudo-second-order kinetic model assumes that chemical adsorption can be the rate limiting stage involving valence forces through sharing or exchange of electrons between adsorbent and adsorbate.
The counter ion diffusivities, which are restricted by electrical forces, are the rate limiting step for CO2 transport through large clusters.
Note that we can neglect any influence of the applied force on the apparent step size, as the stepping rate is independent of force up to 5 pN, most likely because the force-producing step never becomes rate limiting before the complex collapses (Seidel et al, 2004).
In such a model, the height of the rate limiting transition state for unfolding is governed by the strength of interactions between amino-acids which bear the loaded force.
Adsorption rates of N2 and Ar on both materials obey the linear driving force rate equation, indicating that a barrier resistance is rate limiting.
"If the celebs' iCloud account passwords were brute forced, the problem seems to be lack of rate limiting by Apple, not lack of crypto," commented Christopher Soghoian, principal technology at the American Civil Liberties Union.
This suggests that the rate limiting step of this sorption system may be chemisorption involving valency forces through sharing or exchange of electrons between adsorbent and adsorbate.
According to Freund [ 41], the rate limiting factor for alternating movements could be the subtraction of counteractive forces generated by the two antagonistic muscle groups: the contraction of the antagonistic muscle is superimposed on the relaxation of the agonist muscle.
