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Our experience with ERT rate escalation is presented.
We developed a stepwise infusion rate escalation protocol to administer higher dose ERT safely while decreasing infusion duration, which has been implemented in 15 patients to date.
SYNOPSIS A careful stepwise method of enzyme replacement therapy (ERT) rate escalation can safely reduce infusion duration in patients with Pompe disease.
Reported here in detail are five patients with IOPD on 40mg/kg/weekly ERT in whom infusion duration was decreased with individualized, stepwise rate escalation.
The ultimate "quick fix" when it comes to saving for retirement is to automate your contributions and to gradually increase them over time using a contribution rate escalation feature available in many retirement plans.
For example, one way to use automation to your advantage is to gradually increase your contributions over time using a contribution rate escalation feature available in many retirement plans.
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All patients tolerated rate escalations above the recommended rates without experiencing any infusion associated reactions and experienced a reduction in infusion duration by 1h and 24min with a corresponding increase in reported satisfaction.
Rather than executing more instructions per second through clock-rate escalation, superscalar processors execute multiple instructions per clock cycle through parallel execution pipelines.
Other input information, including fuel cost, factor to account for expenses due to installation, instrumentation, engineering and plant start-up, factor to account for power consumption within plant, interest rate and escalation rate have been represented in Table 3.
It is likely to be changed in an economic climate (i.e. due to current interest rate and escalation rate in the prices of coal, maintenance, labour, insurance and pumping power).
The resulting rate of escalation would place the third attack approximately 2 months (66 days) after the second, with the fourth an estimated 52 days after that.
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