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45 Subject ratings followed a similar pattern with an 89% subject-rated responder rate at day 30 and 39% at day 120.

Cells grown on collagen, which enhances cell growth, reached a maximum growth rate at day 2 and this plateaued between days 5 and 6 (data not shown).

On average, we observed the production of orange pigment in 98% of all GT that were incubated at 37°C for 1 7 days, with the lowest detection rate at day 3 for 10 CFU/ml (90%).

Overall, orange pigment was detected in 98% of all GT after incubation at 37°C for 1 7 days, with the lowest detection rate at day 3 for 10 × 10 CFU/ml (90%).

Compared with the control group (fluid alone, 40 patients), the addition of vasopressin (4 IU bolus followed by 2.4 IU/H for 5H, 38 patients) was associated with lower fluid resuscitation volume over 5 days (p = 0.04) with a mortality rate at day 5of25%5% versus 13%, respectively (p = 0.19) [37].

Compared with the control group (fluid alone, 40 patients), the addition of vasopressin (4 IU bolus followed by 2.4 IU/H for 5H, 38 patients) was associated with lower fluid resuscitation volume over 5 days (p = 0.04) with a mortality rate at day 5 of 25% versus 13%, respectively (p = 0.19) [ 37].

The primary endpoint was the survival rate at day 90.

Primary end-point was the mortality rate at day 28.

Maximum respiratory rate at day 1 and SOFA score >7 at day 1 were higher in NIV.

Figure 1 shows the differences in positivity rate at day 0 and 1 of severe sepsis or septic shock.

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Consistent with the reduced replication rate at Day-7, both Rab5 and Rab11, which were up-regulated in the Day-6 population, were down-regulated 4- and 3-fold, respectively, suggesting a reduced need for endocytosis and cytokinesis at this stage of development [ 57, 58].

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