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Inexperienced academic patenters appear to have obtained patents that proved to be less significant (in terms of the rate and breadth of their subsequent citations) than those issuing to more experienced university patenters.
Despite the similar selective pressures on influenza A and B viruses, influenza A virus displays a higher rate and breadth of antigenic variability than influenza B virus.
The magnitude, response rate and breadth of HIV-1 specific T-cell responses in each group and the possible impact of pre-existing Ad5 antibodies on these responses were assessed using an IFN-γ ELISPOT assay.
Reviewer's report Title: Rate and breadth of protein evolution are only weakly correlated Version: 2 Date: 1 November 2011 Reviewer number: 3 Report form: Review of the paper Rate and breadth of protein evolution are only weakly correlated" by SA Naumenko and AS Kondrashov.
Indeed, on a sample of only 11 or 13 genomes, the "real" values of rate and breadth of evolution are determined, for a particular site, only with substantial sampling errors, which reduces their correlation.
Reviewer's report Title: Rate and breadth of protein evolution are only weakly correlated Version: 5 Date: 23 December 2011 Reviewer number: 2 Report form: Nothing further Quality of written English: Acceptable We are thankful to the reviwers for a number of comments which, hopefully, improved our paper.
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The range and breadth of Sarabhai's interests were remarkable.
There is a weak positive correlation between rates and breadths of evolution, both across individual amino acid sites and across proteins.
Table 3 and Figure 3 demonstrate that EP significantly improves the cellular immune response rate, magnitude, duration, and breadth of response to multiple antigens, consistent with previous results demonstrating the improved effect of EP in animal models and in humans with cancer [33] [35].
Rate and breadth are two distinct, and only weakly correlated, characteristics of protein evolution.
A priori, one could expect the rate and the breadth of protein evolution to be positively correlated across sites.
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