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Inexperienced academic patenters appear to have obtained patents that proved to be less significant (in terms of the rate and breadth of their subsequent citations) than those issuing to more experienced university patenters.
Despite the similar selective pressures on influenza A and B viruses, influenza A virus displays a higher rate and breadth of antigenic variability than influenza B virus.
The magnitude, response rate and breadth of HIV-1 specific T-cell responses in each group and the possible impact of pre-existing Ad5 antibodies on these responses were assessed using an IFN-γ ELISPOT assay.
Rate and breadth are two distinct, and only weakly correlated, characteristics of protein evolution.
Reviewer's report Title: Rate and breadth of protein evolution are only weakly correlated Version: 2 Date: 1 November 2011 Reviewer number: 3 Report form: Review of the paper Rate and breadth of protein evolution are only weakly correlated" by SA Naumenko and AS Kondrashov.
Indeed, on a sample of only 11 or 13 genomes, the "real" values of rate and breadth of evolution are determined, for a particular site, only with substantial sampling errors, which reduces their correlation.
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There is a weak positive correlation between rates and breadths of evolution, both across individual amino acid sites and across proteins.
Thus, the rate and the breadth are two different, and only weakly correlated, characteristics of protein evolution.
A priori, one could expect the rate and the breadth of protein evolution to be positively correlated across sites.
Table 1 presents Pearson's and Spearman's correlation coefficients between the rate and the breadth of evolution, calculated from these data.
Our data demonstrate a weak positive correlation between the rate and the breadth of protein evolution across both individual sites and whole proteins (Table 1).
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