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Similar patterns were found in the mouse and rat, with both fructose and glucose stimulating GLP-1 secretion, whereas only glucose caused GIP secretion.
In a study by Watts et al., this model of high-fat diet and low dose STZ was used and directly compared to the ZDF rat, with both models demonstrating the same hepatic and adipose effects, but the errors associated with the ZDF animals were much greater than with the high-fat/STZ model, suggesting that the reproducibility may be improved by using this new model [ 22].
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When his group tested GDF11 levels in rats with both of the assays Wagers had used, a proteomics assay and a commercial antibody, they could not distinguish between GDF11 and myostatin.
Rats with both CPE and LFP electrodes had separate reference and auxiliary electrodes for each circuit.
Over a period of two weeks, they injected rats with both man-made and naturally occurring proteasome inhibitors.
Analyzing 16S rRNA sequences revealed a similar microbiota profile shared between Wistar and Hypertensive rats, with both being divergent from Obese rats.
It has been shown that treatment of rats with both estrogen (E2) and progesterone (P4) for a short period of time protects against mammary carcinogenesis [ 5, 8].
This population was intended to represent rats with both plausible serum BA concentrations and plausible values for the parameters that were varied.
A different pattern of expression of mRNAs was reported after traumatic brain injury in Wistar rats, with both M1 and M2 phenotype – associated markers reaching peak values 5 days after the injury [ 31].
A group from the Bone Division of Geneva showed that SrRan significantly improves mechanical fixation of titanium implants inserted into the tibias of female rats, with both a positive effect on bone microarchitecture and on bone biomaterial properties in the vicinity of the implant.
A similar depletion of GSH levels and mitochondrial toxicity during AZA metabolism were observed in previous studies in primary cultures of rat hepatocytes with both toxic and clinically relevant AZA concentrations [ 5, 10, 25].
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