The present study demonstrated that post-MI rats, which developed HF, display altered plasma peptide profiles when compared to controls.
Insights into the physiology of addiction often come from rats, which develop cravings for some of the same drugs as humans.
The primary hypotheses to be tested in this study were: that post-MI rats which develop HF display altered plasma peptide profiles; and that therapy with the ACE inhibitor ramipril (Ram) may reverse/affect such changes.
We previously reported that angiotensin-converting enzyme inhibitor (ACEi) renoprotection in Munich Wistar Frömter (MWF) rats, which develop progressive glomerular injury, was associated with podocyte repopulation and preservation of glomerular architecture.
Interestingly, in Wistar rats, which develop a certain degree of obesity and do not become diabetic, the diet produced a similar reduction in the expressions of orexigenic and anorexigenic neurotransmitters, suggesting that apoptosis was evenly distributed among neuronal sub-populations.
We also analyzed whether the vascular pathology seen in tgAPP21 rats, which develop amyloid angiopathy, was accelerated by hydrocephalus.
Blocking factors appeared in the serum of rats which developed growing tumours but not in rats whose tumours were suppressed by contact with BCG.
In 30 week old SV-40 Tag rats which developed Grade 4 6 lesions without macroscopic tumors, the prostate tissue weighed 1.27 ± 0.19 grams.
In the present study we analyzed synovial tissues from DA rats, which develop severe arthritis (PIA) with pronounced synovial hyperplasia and cartilage and bone destruction, and synovial tissues from the DA.F344(congenicsngenics, which develop mild and non-erosive disease.
In comparison to STZ-diabetic rats, which develop relatively modest glomerular changes at 6 months of diabetes, glomeruli from the SHR/Ncp rats contained fewer and larger podocytes, smaller mesangial cells and a more expanded mesangial matrix [ 15].
