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Of the 19 visual perception genes identified as inactivated or missing in the naked mole rat, we identified five that have also become pseudogenes in M. davidii but not P. alecto (CYP1A2, RBP3, GUCY2F, CRYBB1, and GRK7; Figure 1).
In analogous searches of the complete genomes of mouse and rat, we identified in each genome 14 chaperonin genes (nine for the canonical CCT monomers, one for the mitochondrial Cpn60, three BBS genes and one CCT8L gene), 38 pseudogenes in mouse and 61 pseudogenes in rat (see additional file 1: Table S1, for mouse sequences, and additional file 2: Table S2, for rat sequences).
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In naked mole-rats, we identified three striated perineal muscles: the IC, LA, and UM (Figure 4; see also [11], [12]).
In the course of extensive microarray analyses of gene expression alterations associated with insulin resistance in adipose tissue from lean and obese humans and rats, we identified OPN as up-regulated in obesity and a TZD target gene [20], [30].
In these rats, we identified a few resorption lacunae near endosteal surfaces (mainly in antero-medial and postero-medial views) which are connected with an early stage of osteoporosis.
Among the 16,241 intron-containing orthologs between mice and rats, we identified 148,176 conserved introns and 937 unique intron positions that might refer to possible intron losses or gains.
Because of the similarity of the Peromyscus genome to the rat genome, we identified regions of the rat genome for which we wanted markers, spacing markers ca. 15 – 20 Mb apart.
Using the viscerally hypersensitive (VH) rat model, we identified perigenual anterior cingulate cortex (pACC) sensitization.
By analyzing a large GeneChip® dataset from the rat intestine, we identified a large cluster of 228 genes that was induced by iron-deprivation.
During a literature search of the cholinergic innervation of the rat cerebellum, we identified two previous anecdotal sources of evidence that cholinergic axons are present in heterotopia.
Similarly, searching the mouse and rat genomes we identified 38 and 61 pseudogenes, respectively (see additional file 1: Table S1 and additional file 2: Table S2).
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