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Whereas the expression of GK, highly decreased in hepatocytes of untreated diabetic rat, was increased at the end of treatment; the HK and PFK-1 genes (decreased or unaltered in diabetic condition, respectively) were decreased significantly at the end of study in the liver, muscle and adipose tissues.
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As shown in Figure 4, the PWT value in the minocycline-treated rats was increased compared with the PWT value in the vehicle-treated control rats.
Expression of β-galactosidase in the Tibialis anterior muscle of Sprague Dawley male rats was increased 250-fold by GET42 compared to DNA injection alone.
The bioavailability of oxymatrine in rats was increased remarkably after oral administration of OMT PLC (p < 0.05), compared with those of oxymatrine or the physical mixture.
AhR protein in rats was increased by VCD dosing in oocyte nuclei in primordial and primary follicles when measured by immunofluorescence and confocal microscopy.
Plasma CCK in high protein-fed rats was increased approximately threefold in the first 24 h, but returned to control (approximately 2.5 pM) values by day 7. Pancreatic weight, DNA, protein, and chymotrypsin ogen) significantly increased to maximal values by day 7 in high protein-fed rats.
In addition, the frequency of mIPSCs from adult rats was increased (Inter-event interval: Control: 52.39±1.67 ms, TTX: 32.86±0.32 ms; Fig 4B; control: n = 11, 4 animals; TTX: n = 8, 4 animals).
On the contrary, the blood glucose level of STZ induced diabetic rats was increased significantly (Group III).
Furthermore, the low antioxidant activity in OLETF rats was increased by ALA treatment.
Glycated heamoglobin (A1c) of STZ-induced treated diabetic rats was increased to a momentous level.
Body weight of male or female rats was increased in a time-dependent manner.
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