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The construct was sequenced, and identity with the published LOX-1 sequence from rat was confirmed.
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The enhanced absorption and uptake of NPs in Caco-2 cells and in vivo absorption in intestinal tissue after oral delivery in rats was confirmed by confocal microscopy.
Increased expression of GSK3ß observed in lungs and PASMC isolated from MCT-induced PAH rats was confirmed to be clinically relevant as the same observation was identified in human iPAH lung explants.
EDH dependence on SKCa and IKCa in the mesenteric artery of normal adult rats was confirmed by selective SKCa and IKCa block [3], [7], [40], and supported via direct endothelial SKCa and IKCa activation with CyPPA and 1-EBIO, and subsequent apamin/TRAM-34 block [16], [28], [29], [30], [41].
The development of hyperglycemia in rats was confirmed by blood glucose evaluation.
Direct target relationship between miR-26a and tlr3 mRNA in rats was confirmed.
Induction of diabetes in the STZ-treated rats was confirmed by blood glucose >20 mM.
Liver damage in diabetic rats was confirmed, as well as improvement in hepatocyte morphology after the C. papaya treatment.
The diabetic status of rats was confirmed by the demonstration of fasting blood glucose level greater than 16.6 mmol/l after 3 days of STZ injection.
The pronounced decrease in minute volume in mice compared with that in rats was confirmed in a study with 15 ppm FA exposure.
Expression of human GLO1 in aortas of the GLO1 Tg rats was confirmed at the transcription and protein levels (Fig. 1B,C).
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